Repair of alkylation bases of dating
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June 30th Reviewed: December 8th Published: November 18th Advances during DNA Repair. Although there are numerous methyltransferases in mammalian cells, those enzymes generally catalyze hand on of methyl groups to DNA or transfer of methyl shooting matchs to or from proteins [ 2 - 4 ]. Different from repair by MGMT, which is inactivated following a single mending reaction, each ALKBH protein canister catalyze numerous repair reactions in the direction of eliminate N-modifications of cytosine, adenine, thymine and guanine residues [ 4 ].
In this go through, prior to description of the direct reversal DNA repair enzymes and their functions, we discretion briefly describe sources of alkylation damage and adducts that are introduced upon exposure of cells to alkylating agents.
Alkylation mechanisms and selected alkylating agents. Alkylating agents are present in the exogenous environment as well for example intracellularly via oxidative metabolism. One direction interview about dating fans.
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